After having a quick look at the state of 'our' portion of the database (the spanish leagues, that is), I believe we have tons of CBs badly rated in terms of response. I think we've rated a lot of them considering their "physical responses" only, in terms of tackling mostly, when that's actually a DEF issue. I mean, look at Ballesteros and his 82 RES... he's a very little adventurous defender, rarely leaves his position in the back four and usually waits for the opposition players to come near him to try a challenge. So there's no need to have him on a yellow RES, he could probably do all right with a low/mid green value.
Another example (I'm using this one because I know them well): Deportivo la Coruña defenders. Currently four CBs: Colotto, Zé Castro, Aythami and Rochela. Aythami is BY FAR the most responsive of them, in fact he's probably too much responsive for his own good (tends to leave huge gaps in defense due to his interception attempts), he should probably have a mid/high yellow number (in the 86-88 range). But the others... Colotto and Zé Castro are usually calm and collected defenders, do not leave their position much. They do not need a great RES value to be well replicated ingame. Anything in the 75 - 78 range would suit them well. And then Rochela... a bit more adventurous than those two, but still, no need to go over 79-80 for him.
Note that having 86 in RES won't make Aythami a better defender than the others. That's a matter of DEF (effectivity at marking, tackling and disposessing opposition players) and TW (coordination capacity with teanmates, ability to 'read the game' and such things)... stats where Colotto should clearly shine above the other three.